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Yes, US switchgear is marked L, N, ⏚ for outlet neutral on the left ("V" orientation, ground prong at the bottom), as is UK switchgear ("A" orientation, outlet neutral on the left). Even CEE 7/3 and CEE 7/5 sockets as widely use in mainland Europe are marked for live on the left ("A" orientation, ground prong/hole at the top) so that angled plugs hang downwards, but this is poorly upheld. IEC C14 inlets as used worldwide on gear are marked too, for live on the left ("A" orientation, ground prong at the top).Thanks for that explanation.
Are there rules in the US how to wire LN pins on power outlets? If yes, there is only one possible pin assignment, which an appliance designer can rely on. He can design the appliance in a way that works best with the pin assignment specified by the outlet. Pin swapping is not necessary and as a result, gadgets such as the GND Defender become obsolete (provided it works the way you described, which sounds plausible to me).
If there is no rule regarding wiring of LN pins on outlets (like in Germany and other EU countries), the position of the N pin is not always the same. In this case, the appliance designer should design the appliance in a way that it works good with any pin assignment. If he does so, pin swapping again is not necessary and the GND Defender is still obsolete.
On un-keyed outlets you can swap manually by simply turning the plug. That makes the GND Defender obsolete as well.
Besides that, there is one special situation in Europe, which also can happen in the US, I guess:
There are ungrounded appliances that have a 2-pin plug without a ground pin (for instance some HiFi gear). But regardless of the missing ground pin, these appliances do have EMI/RFI protection. As there is no ground pin, RFI protection consists of one condenser wired between the L pin and the housing and another condenser of the same capacity wired between the N pin and the housing. In this configuration, these condensers act as an AC voltage divider applying half of the mains voltage to the housing. In a 110V grid, this means that you can measure 55V AC from the housing to ground. However, the capacities of these condensers (around 10 nF) don't allow for currents that are dangerous to humans. You only can feel a little prickle when touching the housing of such an appliance. But regarding audio signals, 55 V is a lot and it definitely will cause hum noise when connecting a RFI-protected, non-grounded appliance with a grounded one. It also will feed AC to the ground pin of the grounded device, which is one of the reasons why ground potential is not always the same on all outlets in the house.
So in summary:
1. US gear used in the US is fine (everything is keyed)
2. EU gear used in 'unkeyed' EU is fine (designed for unkeyed)
3. US gear used in 'unkeyed' EU is a concern (designed for keyed)
For 3. you want to make sure to plug in correctly. Connecting US gear the wrong way can damage the RFI filter, which makes matters worse. For decent mains installations it is possible to construct an adapter that auto-detects LN and corrects the connection automatically. In installations with a dirty neutral (long wires, high load) auto-detection can be a problem.
Two-prong gear (like many wall warts) is different. It is double isolated to provide safe galvanic isolation between mains and appliance power. There is no mains ground connection to the outer shell nor should there be any prickle on pro audio gear. There can be a signal ground connection though, to extend audio cable shielding to the appliance's case.